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References Ghanem H, Glina S, Assalian P, Buvat J

Most metabolic inhibitors targeting cancer remain in preclinical phases, but glutamine-depleting L-asparaginases have already been approved as a standard component of a therapeutic regimen for acute lymphoblastic leukemia (223)

Despite its importance, few is known about actors involved in human gut barrier function, since most of the data are limited to animal studies which have shown that microbiota changes can promote disruption of intestinal barrier homeostasis [37]

This is especially true with long-term or repeated use of pain medications, where short-term relief can mask progressive systemic side effects

Dysregulated gut homeostasis observed prior to the accumulation of the brain amyloid- in Tg2576 mice