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More serious but rare side effects include increased blood pressure, heart palpitations, dizziness, restlessness, tremors, insomnia, shortness of breath, chest pain, severe skin reactions, and swelling in the legs and ankles

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The Frias 2023 Phase 2 in T2D showed cagrilintide+semaglutide produced a -2.2 percentage-point HbA1c reduction at 32 weeks versus -1.8 for semaglutide alone