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Although folic acid is readily absorbed thanks to its single glutamate residue, it is not active as a coenzyme: the enzyme dihydrofolate reductase (DHFR) needs to convert it to tetrahydrofolate for further use [ R , R ]

The expression and activation of YAP and YY1 in the endothelium is triggered by shear stress alterations, and both TFs exert pro-atherogenic effects in vivo, which [43, 44] could be further enhanced by lactylation

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[DOI] [PMC free article] [PubMed] [Google Scholar] 123.McCarthy K., Laban C., McVittie C.J., Ogunkolade W., Khalaf S., Bustin S., Carpenter R., Jenkins P.J

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