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The GSH-EE group (n=24) was treated with 0.1 mL GSH-EE injected intraperitoneally once daily during the 3 days before OVA challenge

The endogenous pathways for the degradation of histamine require either methylation (SAMe, Mg 2+ , and ATP) or mitochondrial ALDH

Therefore, scientific evidence highlights the importance of early oxidative stress in the CIPN onset

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The inhibition of PTP1B results in a prolonged insulin signaling cascade, thereby increasing insulin sensitivity