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Se-methylselenocysteine sensitizes hypoxic tumor cells to irinotecan by targeting hypoxia-inducible factor 1alpha

Alternative modular expression of the polyketide synthetase pikAIV has been reported to be involved in the generation of two macrolactones differing in size while a potential contribution of alternative gene expression to the structural diversification of NRPS products still needs to be deciphered 35

10.1016/j.currproblcancer.2021.100729 12 ChaabenA

Nearly all cells in the four groups highly expressed the hepatic progenitor markers HNF4 and AFP

Oxidative stress can disrupt these tolerance mechanisms by inducing apoptosis of regulatory T cells (Tregs), which are critical for maintaining immune homeostasis and preventing autoimmunity [141]