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Although complaints about irritability and increased sensitivity to everyday stressors have long been recognized clinically in alcoholic patients, corresponding human data are just beginning to emerge

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The score (the ancestor of the current MELD score), derived from a survival function, was calculated as follows: R=0.957 Loge(creatinine [mg/dl])+0.378 Loge(bilirubin [mg/dl])+1.120 loge (Prothrombin Time-International Normalized Ratio)+0.643 (cause of cirrhosis)