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doi: 10.3390/ijms222413384

Figure 5 While immune complexes are known to be immunogenic, immune complex-mediated immunogenicity is typically driven by mechanisms that are lacking from the aglycosylated SEFL Fc domain of AMG 966, such as FcR binding ( in vitro and assessed binding to FcRIa, FcRIIa, and FcRIIIa compared to AMG 966 alone in a competitive AlphaLISA binding assay

The number of neurons in the entorhinal cortex and hippocampus is significantly reduced in patients with AD [24,27]

AOD 9604 has a more developed safety profile by virtue of its human trial history

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