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In the Xenopus oocyte expression system, it is possible to observe an acute desensitization of DOR on potassium channels (Kir3) elicited by DPDPE without significant internalization measured by surface biotinylation (Celver et al., In contrast, the abolition of rKOR internalization by the S369A substitution also inhibits receptor desensitization on potassium currents (Mclaughlin et al., Those data demonstrate that desensitization and internalization are usually two independent processes although in some situations a close relationship could be evidenced

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There was also a significant reduction of ROS levels (Fig

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