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Distribution In the blood, B12 is bound to transcobalamin II, a specific B-globulin carrier protein, and is distributed and stored primarily in the liver and bone marrow
Expert Opinion on Biological Therapy , 12 (1), 3751
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Vitamin B12 may also play an important role in bone health, as studies have shown that low blood levels of B12 can be associated with an increased risk of osteoporosis in women
Several formulation variables plausibly influence irritation: the concentration of the serum, the carrier and any preservatives, and how frequently it's applied
