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or off-target pharmacol

SCFAs can induce gluconeogenesis, reduce inflammation, and directly interact with vagus nerve afferent nerves (De Vadder et al., 2014

Retatrutide is a triple hormone receptor agonist, acting on three receptors simultaneously: GLP-1 (glucagon-like peptide-1) reduces appetite and slows gastric emptying GIP (glucose-dependent insulinotropic polypeptide) enhances insulin secretion and may improve fat metabolism Glucagon receptor increases energy expenditure and promotes fat breakdown It is worth noting that glucagon receptor agonism can, in isolation, raise blood glucose levels

Although these findings have generated considerable interest, the majority of available evidence comes from laboratory and animal studies rather than large human clinical trials

DOI 10.1001/jama.2022.0470 Davies M, et al