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Although a detailed description of PPI is beyond the aim of our review, such network partially recapitulates the peculiar crosstalk and close association between the intrinsic biological clock and the intracellular signaling pathways described above, with relevant implications in the therapeutic management of diseases
doi: ^ Soty M., Chilloux J., Delalande F., Zitoun C., Bertile F., Mithieux G., and Gautier-Stein A
J Biol Chem 286(14):1274312755 Wang Q, Mora-Jensen H, Weniger MA, Perez-Galan P, Wolford C, Hai T et al (2009) ERAD inhibitors integrate ER stress with an epigenetic mechanism to activate BH3-only protein NOXA in cancer cells
Investigation of optimal combination protocols represents another important research direction
