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If tolerance is good and no concerning reactions occur, consider increasing to twice-daily application or moving to a 1 percent concentration

Bhattacharjee, M., Bhattacharjee, S., Gupta, A., and Banerjee, R.K., Free Radic
This is possibly due to gegen's vasodilatory effect, which could be a result of its ability to activate calcium-activated potassium channels in rat thoracic aorta (Sun et al., 2007

Abdel Hameid, R., Cormet-Boyaka, E., Kuebler, W

For people whove been told they just have to live with it, this changes the conversation
