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In addition, berberine affected the expression of several proteins important in tumor cell cycle progression, These proteins include Cyclin-D1, Cyclin-B1, Cdc25, CDK1, Epidermal Growth Factor (EGF), Raf/MEK/ERK, and Platelet-derived growth factor (PDGF), activated enhancer-binding protein-1 (AP-1), AP-2, and CD147 [240]
Thyroid hormone replacement therapy is a well-established and effective treatment for managing hypothyroidism and other conditions leading to reduced thyroid hormone production
