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However, it has not been approved for use in standard medicine by the FDA and other global regulatory authorities due to the absence of sufficient and comprehensive clinical studies confirming its health benefits in humans

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From a mechanistic perspective, chronic iron accumulation creates a permissive environment for ferroptosis by increasing the labile iron pool, promoting lipid peroxidation, and overwhelming antioxidant defense systems such as the GPX4glutathione axis

Catalysis of disulphide bond formation in the endoplasmic reticulum
