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Ddx41 was identified as the gene targeted by miR-218-5p, which was validated through luciferase reporter assay

They have identified four isozymes of superoxide dismutase: (i) SOD1 is a metalloprotein binding copper and zinc ions that are localized in the cytosol of the cell [55, 56], (ii) SOD2, localized in the mitochondria and it is associated with the manganese or iron ions [56, 57], (iii) SOD3, localization is extracellular and is also associated with the copper and zinc, although it has a high molecular weight [56, 58] and it has high affinity for heparin and heparin sulfates [59], and (iv) SOD4 associated with nickel and found in various aerobic bacteria found in soil of class of Streptomyces [60, 61]

Peer review Peer review information Nature Communications thanks Anna Benrick, Kangling Zhang, and the other, anonymous, reviewer for their contribution to the peer review of this work

Because clove oil components are volatile, hydrophobic, and metabolically labile, many investigators are exploring advanced formulations to enhance their stability, solubility, and antimicrobial efficacy

Abbreviations The following abbreviations are used in this manuscript: Author Contributions Wrote the manuscript: S.N