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Fluids Barriers CNS 17:69 Kido Y, Tamai I, Ohnari A, Sai Y, Kagami T, Nezu J, Nikaido H, Hashimoto N, Asano M, Tsuji A (2001) Functional relevance of carnitine transporter OCTN2 to brain distribution of l-carnitine and acetyl-l-carnitine across the bloodbrain barrier

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Dose Adjustments and Specific Patient Populations: Renal Insufficiency: In patients with ESRD, the IV route is preferred because the kidneys cannot clear the drug

Additionally, the modulation of cystine-glutamate exchange via the system x c has been suggested as a new strategy to diminish the excitatory glutamatergic transmission observed after drugs of abuse, while drugs that influence that systemsuch as N-acetylcysteine (NAC)were considered as promising targets for the development of novel pharmacotherapies of SUD