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In another study, it was found that the essential oil of ZBE suppressed TNF-, IL-1, and IL-12 levels both in vivo and in vitro, as well as NLRP3 inflammasome activation in vivo [238]

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When ligand binds to PPAR the co-repressor complex dissociates and a co-activator complex containing histone acetyltransferase associates resulting in chromatin structural changes and transcriptional activation