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Based on human and animal studies, any systemic effects attributable to orlistat's ability to inhibit lipases should be rapidly reversible

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High glycine concentration increases collagen synthesis by articular chondrocytes in vitro: acute glycine deficiency could be an important cause of osteoarthritis

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[25] Up-regulation or activation of transcription results in increased synthesis of messenger RNA, which, in turn, is translated by ribosomes to produce specific proteins