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This allowed cross-referencing of the IVs with cancer-related GWAS data, ensuring that no significant associations with other known confounders, such as smoking, alcohol consumption, or other lifestyle factors, were overlooked

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Topical therapy One significant concern with oral medications is the ability to deliver the drug to the target tissues in a high enough quantity to exert their effectsparticularly given the lack of significant vascularity within the plaque

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