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We propose that NADPH and GSSG convey TCA cycle status: decreasing the availability of acetyl-CoAeither from lipid or carbohydrate catabolismdampens NADPH production and disfavors glutathione reduction, with the increased GSSG ultimatelyeither directly or indirectlyaltering ER oxidative protein maturation and protecting ER homeostasis

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In animal models, genistein blocks allergen-induced airway inflammation in ex vivo allergen-challenged guinea-pig bronchi and lung specimens

Total RNA was isolated from cells using the RNAfast200 Kit (Fastagen Biotech, Shanghai, China)

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