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The mechanisms involved in ferroptosis and their interconnections are summarized in Fig

Nevertheless, our genetic loss-of-function and gain-of-function experiments consistently support SIRT7 as a key mediator of protective effects of NMN in VSMC phenotype maintenance and AAA pathogenesis, although there may be other parallel pathological mechanisms independently contributing to AAA

Blockage of the efflux transporter System x c abrogates the negative effect of glioma cells on their microenvironment

Bile acid-gut microbiota crosstalk in irritable bowel syndrome

1D228 showed improved anti-tumor effect compared with Tepotinib in vivo The data obtained from the in vitro experiment provided evidence of the strong anti-tumor cell properties of 1D228