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We used TSQ (6-methoxy-8-p-toluenesulfonamido-quinoline) staining to measure intracellular zinc levels 50 and observed significantly higher zinc levels in islets from patients with T2D than in those from ND controls (Fig

The dosage should be based on berberine content

Notably, bile acid signaling pathways can also contribute to OA pathology, as indicated by the alleviation of murine OA after suppression of farnesoid X receptor-the receptor for the bile acid glycoursodeoxycholic acid (GUDCA), which upregulates intestinal glucagon-like peptide-1 secretion (Yang et al., 2025)

The study was based only on data from the published literature, did not allow for prospective or randomized controlled trials, and did not explore the direct associations between drug penetration ratios and adverse fetal or neonatal outcomes