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While the combination of herbal products may have added benefits, such studies are not included in this review as they further complicate the identification of the action source

Petraglia A., Plog B., Dayawansa S., et al., The Pathophysiology Underlying Repetitive Mild Traumatic Brain Injury in a Novel Mouse Model of Chronic Traumatic Encephalopathy, Surgical Neurology International 5 (2014): 184, 10.4103/2152-7806.147566

Entacapone, the most commonly used peripherally selective inhibitor, carries no hepatotoxicity risk but must be administered concomitantly with each L-DOPA dose [121]

All animals were kept in stainless-steel mesh-bottomed cages in the Department of Physiology, Faculty of Medicine, Zagazig University, in aseptic conditions, with a temperature range from 20C to 24C, suitable humidity (50%60%), and a 12:12 h light/dark cycle

We and others have performed SAR optimization and synthesized prodrugs of analogs to target M