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Beyond Fat Loss: Cartilage and Joint Health Data A 2015 rabbit osteoarthritis model found that intra-articular injection of AOD-9604 at 0.25 mg weekly over 47 weeks enhanced cartilage regeneration, with greater effect when combined with hyaluronic acid

Kraus D, Yang Q, Kong D, Banks AS, Zhang L, Rodgers JT, Pirinen E, Pulinilkunnil TC, Gong F, Wang YC, Cen Y, Sauve AA, Asara JM, Peroni OD, Monia BP, Bhanot S, Alhonen L, Puigserver P, Kahn BB

First, the code covers both epidural and subarachnoid space injections, so the report need not specify which compartment was accessed

It upregulates genes involved in collagen synthesis (COL1A1, COL3A1, COL5A1), extracellular matrix remodeling (decorin, fibromodulin), and antioxidant defense (superoxide dismutase, glutathione peroxidase) while simultaneously suppressing genes associated with inflammation (IL-6, TNF-alpha), fibrinogen production, and tissue destruction (several MMPs)