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ISCs are involved in electron transport, substrate binding, enzymatic catalysis and play critical roles in maintaining genomic stability since several DNA polymerases and helicases require interaction with ISCs for proper functioning
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It has been widely reported that an exercise bout consisting of eccentric muscle contractions can result in substantial damage to the contractile unit, which often results in inflammation, loss of Ca 2+ homeostasis and possibly induction apoptosis as a result
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