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Description
In macrophage and microglial models, fisetin was reported to downregulate iNOS, COX-2, and TNF-, while inhibiting the nuclear translocation of NF-B (p65) and phosphorylation of upstream kinases such as Src, Syk, and JNK [54,55,56]
ME-3 consumption leads to an increase of the reduced/oxidized glutathione ratio in the body, and to an overall improvement of oxidative status
G.NielsenF
Statements Author contributions PS: Conceptualization, Data curation, Funding acquisition, Investigation, Visualization, Writing original draft, Writing review & editing
Rossi M, Abdelmohsen K (2021) The emergence of senescent surface biomarkers as senotherapeutic targets
