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Preclinical studies have demonstrated that esterbased CMS nanocarriers (e.g., CMS 10E15350) exhibit excellent biocompatibility, rapidly penetrate oral mucosal tissues within minutes, and do not compromise the epithelial barrier or induce a proinflammatory response [177]

Prioritization of cancer therapeutic targets using CRISPR-Cas9 screens

[DOI] [PubMed] [Google Scholar] 132.Mody I., Stanton P.K., Heinemann U

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Beyond bulk analyses, single-cell technologies such as single-cell RNA sequencing (scRNA-seq) and spatial transcriptomics/metabolomics are now providing unprecedented resolution of cellular heterogeneity and spatio-temporal BA signaling within the TIME and associated mucosal tissues (177)