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doi:10.3390/nu7042748

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For example, the triple agonist Retatrutide targeting GIPR/GLP-1R/GCGR and the dual agonist Survodutide targeting GCGR/GLP-1R are currently in Phase III clinical trials 4-6

In each case, a provider should confirm a deficiency before starting treatment

Preclinical reviews of amylin and the related peptide calcitonin have specifically proposed these agents as strategies to reduce both body weight and liver fat, citing improvements in hepatic steatosis in rodent models of diet-induced obesity