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Persistent ferroptosis in alveolar and endothelial cells triggers pro-fibrotic signaling pathways, such as those involving TGF- and connective tissue growth factor (CTGF), which drive ECM deposition and fibroproliferation

While Keap-1 acts as the inhibitor of Nrf-2 and controls its stability

35 Reduction in depressive symptoms and benefits in quality of life were also found in secondary analysis of other studies

Emerging therapeutic strategies for SLE extend beyond B cell depletion to target CD4 follicular helper T (Tfh) cells: E4BP4 inhibits Tfh differentiation by repressing BCL-6 transcription via recruitment of HDAC1 and EZH2, while impaired E4BP4 function and IFN-Idriven IL-21/IFN- production promote Tfh expansion and autoreactive B cell responses, supporting Tfh-directed CAR-T approaches (54, 55)

Fecal microbiota transplantation affects the recovery of AD-skin lesions and enhances gut microbiota homeostasis