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Studies on resistance development against anticancer thiosemicarbazones have underscored the importance of essential metal ions, including Fe(II), Cu(II), and Zn(II)(Psa et al

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Inhibition of eNOS reduces this relaxing effect, suggesting that this metabolite lowers blood pressure primarily by promoting NO release from endothelial cells, thereby facilitating vascular relaxation (Dias et al., 2022)

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