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At the beginning of the 2022, the US FDA's Center for Drug Evaluation and Research (CDER) released the novel drug approval report for 2021

Smolen JS, Aletaha D, McInnes IB

TXNIP, a novel key factor to cause schwann cell dysfunction in diabetic peripheral neuropathy, under the regulation of PI3K/Akt pathway inhibition-induced DNMT1 and DNMT3a overexpression

They discovered that circ-0000231 acts through the circ-0000231/miR-140/RAP1B axis, leading to increased expression of E-cadherin in paclitaxel-resistant tumor cells

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