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doi: 10.1172/JCI69600
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187 The PDE4 inhibitor roflumilast has been approved by the Food and Drug Administration as a COPD treatment
It also downregulates NF-B and upregulates Nrf-2 [135,136,137]
Zhao H, Osborne OJ, Lin S, Ji Z, Damoiseux R, Wang Y, Nel AE, Lin S., "Lanthanide Hydroxide Nanoparticles Induce Angiogenesis via ROS-Sensitive Signaling", Small 12 (32): 4404-4411 (2016)
