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Redox-mediated inactivation of MGMT DNA repair through thiolation or nitrosylation of the active site cysteine145 sensitizes human gliomas to alkylating agents in vitro and in xenograft models

Peng F, Liao M, Qin R, Zhu S, Peng C, Fu L, Chen Y, Han B

254,255 Keap1/Nrf2/ARE signaling pathways As mentioned, the NF-B, MAPK, and JAK-STAT (signal transducers and activators of transcription) signaling pathways are involved in the development of inflammation

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91 In UC patients, endoplasmic reticulum function may be impaired, leading to abnormal accumulation of intracellular proteins and exacerbation of the cellular inflammatory response