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World J Hepatol 2021;13:1688-98

Figure 1 3.2 Lipid peroxidation and oxidative stress Ferroptosis is ultimately driven by ROS-mediated lipid peroxidation

The pentapeptide structure includes aminoisobutyric acid (Aib) at position 1 for N-terminal stability, D-2-naphthylalanine (D-2-Nal) and D-phenylalanine (D-Phe) at positions 3 and 4 for protease resistance and receptor binding, and a C-terminal amidated lysine preventing carboxypeptidase degradation