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Unfortunately, despite animal model studies showing that functional HDL-C plays a role in limiting atherosclerosis progression and stimulating plaque regression, increasing HDL-C levels in human trials has failed to provide convincing evidence of health benefits [55]

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R package version 1.0.12 Lee D, An SWA, Jung Y, Yamaoka Y, Ryu Y, Goh GYS, Beigi A, Yang JS, Jung GY, Ma DK et al (2019) MDT15/MED15 permits longevity at low temperature via enhancing lipidostasis and proteostasis