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The 16 overlapping phosphoproteins confirmed former results published by Bahl et al

The binding of C-Met to HGF initiates the receptors innate kinase activity, followed by the formation of a multisubstrate docking site for the intracellular junction protein, which recruits signaling molecules due to homologous dimerization and autophosphorylation at Tyr1234 and Tyr1235 and subsequent phosphorylation at Tyr1349 and Tyr1356 at the c-terminal tail (Birchmeier et al., 2003

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Gojkovic S, Krezic I, Vrdoljak B, Malekinusic D, Barisic I, Petrovic A, et al

This was groundbreaking at the time, as it became the first fully synthetic drug used to treat an infectious disease