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TB-500 (Thymosin Beta-4) TB-500 is a synthetic version of a naturally occurring protein involved in tissue regeneration and cell migration

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Patients considering combination approaches should understand that this represents an unproven strategy that increases cost and injection burden without documented benefit

Collectively, these immuneneural interactions create a pro-nociceptive and pro-regenerative milieu in wounds, setting the stage upon which pharmacological agents act either by dampening inflammatory sensitization or by directly reducing nociceptor excitability