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Oxygen toxicity Discovery of oxygen toxicity Although organisms have developed complex mechanisms to adapt to hypoxia (such as HIF and HIFPHD signalling), given that atmospheric oxygen concentrations that are higher than current levels are rarely encountered, land mammals are less well equipped to adapt to hyperoxia 45

Side-effect management: Nausea and GI issues are minimal at lower doses

This is even the case with subclinical thyroid disorders in which there is a mild impairment in thyroid hormone levels without frank overt symptoms (Glenwright 2023)

Mallia-Milanes B, Dufour A, Philp C, Solis N, Klein T, Fischer M, et al

14 Considering that both Nrf2 and COX-2 regulate inflammation, Nrf2 may act as a link between COX-2 and ferroptosis in the context of chronic liver injury