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Versus near-zero through intact skin under identical conditions 3

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Tsimikas, S

A more comprehensive approach would be to concurrently measure actual protein levels (e.g., WB, ELISA, etc.) of potential targets in addition to inhibitor assays

No tolerance development to the lipolytic effects was noted in these studies, suggesting that unlike beta-2 agonists (which rapidly desensitize their receptors), beta-3 receptor activation may not produce the same downregulation pattern