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J Clin Invest 90 : 23482354 Biolo G et al

Licensed, NICE-approved alternatives for weight management including semaglutide (Wegovy) and tirzepatide (Zepbound) are available through NHS and regulated private UK healthcare pathways

The B12 addition is about supporting overall health during treatment, not enhancing the weight loss effect itself

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Cre ERT2 is a recombinant fusion protein of the Cre DNA recombinase and a mutant ligand-binding domain of the human estrogen receptor
