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In animal systems, the built-up of MG produces ROS, resulting in cellular oxidative stress [182]
Antioxidants 10 (3), 414
Research has documented healing effects on tendons, ligaments, muscles, nerves, blood vessels, and organs including the liver, pancreas, and gastrointestinal tract
Consequently, System Xc- inhibitors cannot induce cellular ferroptosis in these cells [123]
In vitro cell uptake tests revealed that these nanoparticles exhibited targeted properties for glioma cells, and compared with non-targeted nanoparticles, targeted nanoparticles showed better BBB penetration in the in vitro model [383]
