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Intermittent hypoxemia and OSA: Implications for comorbidities

Epithelial to mesenchymal transition (EMT) is the major reason for metastasis, where epithelial cells lose their cell-cell adhesion property, polarity, subsequently leads to cell mobility [35]

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In human skin fibroblasts, Nrf2-driven antioxidant enzyme expression translated into: Reduced intracellular ROS Improved mitochondrial membrane potential Protection against senescence-associated cell damage [36] In human gingival and periodontal stem cells, Epitalon significantly reduced aging biomarkers such as p16 and p21, decreased ROS levels, and preserved mitochondrial function, even under stress [42]