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Nabe S, Yamada T, Suzuki J, Toriyama K, Yasuoka T, Kuwahara M, et al

10 GSH synthetase catalyses the second and final step in the de novo synthesis of GSH through the conjugation of glycine with -glutamylcysteine

Salvianolic acid B inhibits myocardial I/R-induced ROS generation and cell apoptosis by regulating the TRIM8/GPX1 pathway

For example, curcumin has been evaluated in Phase II clinical studies in pancreatic cancer and colorectal cancer patients, where oral doses up to 8 g/day demonstrated acceptable safety but limited systemic exposure, highlighting pharmacokinetic challenges