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Experimental proof demonstrated PPAR- as the prime controller of hepatic -oxidation and microsomal -oxidation which were markedly decreased by high lipid diet

doi: 10.1080/10715762.2023.2166504 161 GhodakeSRSuryakarANAnkushRDKatkamRVShaikhKKattaAV

Cadavid, D

The dihydropyridine L-type calcium channel blocker Isradipine has been reported to reduce hypoxia-induced activation of Ca 2+ -dependent xanthine oxidases, monoamine oxidases, cytosolic phospholipase A 2 , and cyclo-oxygenases (COX-2) along with a decrease in free radical generation and cytochrome- c release (Barhwal et al., 1991) was also inhibited by Isradipine

Microglia then break down ATP into adenosine, which binds to adenosine receptors on the surface of active neurons