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Notably, the peptide is believed to possess a greater affinity for MC1R over -MSH, suggesting that it might increase melanin production, thereby promoting skin pigmentation even in the absence of sunlight exposure

Yang 2015

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Individuals with a history of gastrointestinal disorders, such as ulcers or inflammatory bowel disease, or chronic diseases such as liver or kidney disease are at higher risk of developing Melaena

The authors conclude that this antioxidant-based support is well tolerated and may provide clinically meaningful benefits, although controlled trials are needed to confirm efficacy (Cucinotta et al., 2022)