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Gut Microbiota Dysbiosis and Abnormal Gut Microbiota-Host Co-Metabolites Gut microbiota can provide the host with biological enzymes and biotransformation pathways that the human body does not possess, and co-metabolize with the host, producing metabolites such as vitamins, fatty acids, bile acids and trimethylamine N-oxide (TMAO) and other metabolites through various metabolic pathways and transferring them to the circulatory system, thus regulating the microenvironment and function of the brain

It shows up as a slowing of recall, difficulty sustaining concentration, and a general sense that the brain is not as sharp as it once was

Tube areas were quantified as the ratio of the area of the formed tubes to that of the imaged field using the Scion Image 4.0.3 program (Scion Corp.), and the ratio of tube areas of vehicle treatment or control was regarded as 1.0

doi: 10.1016/j.neurobiolaging.2014.03.040

This uncertainty cannot be resolved without longitudinal human data that does not currently exist