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Vitamin B12 plays a significant role in maintaining the metabolic balance of skin cells, so when the body lacks sufficient B12 levels, it impacts melanin production

Mechanism: Increased satiety signalling Delayed gastric emptying Reduced caloric intake It does not directly influence glucagon-mediated energy output

[DOI] [PMC free article] [PubMed] [Google Scholar] 299.Castro-Torres R.D., Urea-Guerrero M.E., Morales-Chacn L.M., Lorigados-Pedre L., Estupian-Daz B., Rocha L., Orozco-Surez S., Rivera-Cervantes M.C., Alonso-Vanegas M., Beas-Zrate C.J

The most significant concern is reduced dietary intake due to appetite suppression and gastrointestinal side effects

Sanz-Cuesta T, Escortell-Mayor E, Cura-Gonzalez I et al (2020) Oral versus intramuscular administration of vitamin B12 for vitamin B12 deficiency in primary care: a pragmatic, randomized, non-inferiority clinical trial (OB12)