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Role of T lymphocytes and interferon-gamma in ischemic stroke

Abbreviations AKI: Acute kidney injury ATP: Adenosine triphosphate AdMSCs: Adipose-derived mesenchymal stem cells Ki-67: Antigen Kiel 67 Bcl2: B-cell leukemia BVN-Tb4: BVN-thymosin 4 GPX4: Glutathione peroxidase 4 CGD: Chronic granulomatous disease CRRT: Continuous renal replacement therapy DAPK1: Death-associated protein kinase 1 EPCs: Endothelial progenitor cells ERK: Extracellular signal-regulated protein kinases ESC: Endothelial stem cells FGFR: Fibroblast growth factor receptor GDM: Gestational diabetes mellitus GLI2: Glioma-Associated Oncogene Family Zinc Finger 2 HSC: Hepatic stellate cell HUVECs: Human umbilical vein endothelial cells HIF-1: Hypoxia-inducible factor 1-alpha IB: Inhibitor of nuclear factor kappa B IGF-1: Insulin like growth factor 1 receptor IL: Interleukins IL-8 mRNA: Interleukin-8 messenger Ribonucleic acid LAP: LC3-associated phagocytosis LC3-II: LC3-phosphatidylethanolamine conjugate LPS: Lipopolysaccharide LC3B: Microtubule-associated protein 1A/1B light chain 3B MAPK: Mitogen-activated protein kinase MHV-A59: Mouse hepatitis virus A59 Nrf2: Nuclear factor erythroid 2-related factor 2 NF-B: Nuclear factor kappa B NLRP3: Nucleotide-binding domain, leucine-rich repeat, and pyrin domain-containing protein 3 PI3K: Phosphatidylinositol 3-kinase p38: P38 mitogen-activated protein kinase ROS: Reactive oxygen species rhT4: Recombinant human thymosin 4 SeNPs: Selenium nanoparticles SOD: Superoxide dismutase TdT: Terminal deoxynucleotidyl transferase TB4: Thymosin beta-4 TLR4: Toll-like receptor TNF-: Tumor necrosis factor alpha TM: Tympanic membrane T2DM: Type 2 diabetes mellitus VEGF: Vascular endothelial growth factor VIP: Vasoactive intestinal peptide References Mohan V, Joshi S, Mithal A, Kesavadev J, Unnikrishnan AG, Saboo B, Kumar P, Chawla M, Bhograj A, Kovil R

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They also looked at melittins anti-inflammatory properties through its associations with IKKs