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The role of DNA strand breaks in human spermatozoa used for IVF and ICSI
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Although ascorbate can penetrate into the CNS through the choroid plexus, it cannot cross through the blood-brain barrier because the tight junctions of the endothelium do not allow ascorbate transport through the paracellular pathway (Harrison and May, 2009)

Nevertheless, this pattern cannot be differentiated from a false positive EIA result, the exact prevalence of which is unknown