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Pro-inflammatory cytokines such as tumour necrosis factor beta (TNF), interferon alpha (IFN), interleukin-1 (IL-1), IL-5, and IL-16 are found upregulated, whereas the anti-inflammatory cytokines IL-4 and IL-13 are downregulated, resulting in an inflammatory process that causes neuronal damage and contributes to ADHD symptomatology [60]

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In recent years, a synthetic peptide called Dihexa has emerged as a promising cognitive enhancer for improving certain cognitive functions, cognitive enhancement, learning and long term memory capacity

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The search was performed in multiple databases, including PubMed, Web of Science, and Embase, and was supplemented by manual searches using Google Scholar to ensure completeness